Climate models are a powerful tool for studying the climate system and climate change, and the simulation results of climate models are an important data base for climate projection and risk evaluation of climate change. With the acceleration of global warming, the surface ecological environment, hydrological dynamic cycle and the development of social economy will be affected, which will also affect human safety. To evaluate and predict the future climate change features by using climate models can provide a scientific basis for adjusting human development strategies to adapt to climate change. The paper summarized domestic researches of the CMIP5 (Coupled Model Intercomparison Project Phase 5) global climate model in climate change, then summed up the application of the CMIP5 climate model in agricultural production, hydrologic dynamic monitoring and others. Finally, the paper points out the insufficiency of the CMIP5 climate model in the projection of climate change and prospects the future of the CMIP5 climate model.