Using the meteorological observation data of Yuepuhu in Xinjiang from 1981 to 2019, combined with the growth and development of Flos Lonicerae, the relationship between the climatic conditions and the growth of Flos Lonicerae in Yuepuhu are analyzed. According to the ecological characteristics of Flos Lonicerae, the meteorological conditions of Flos Lonicerae cultivation in Yuepuhu are systematically analyzed, and the results show that the average temperature of each phenological stage of Flos Lonicerae in Yuepuhu show an obvious increasing trend; the number of sunshine hours has an obvious increasing trend; and the water source is sufficient. These are conducive to the normal growth and development of Flos Lonicerae. As the temperature rises and the number of sunshine hours increases, the planting time has been advanced from the previous midMarch to early March; the planting area has expanded year by year, from tens of hectares in 2016 to 345 hm2 in 2019; and the planting mode has been adjusted from the plain cropping to intercropping method. In the interplanting mode, the varieties are unified with Beihua No.1. The number of consecutive high temperature days of ≥38 ℃ during the growth and development of Flos Lonicerae, especially in ≥40 ℃ high temperature weather, the shortterm heavy precipitation weather, windy and sandy weather and other meteorological conditions have certain influence on the quality and yield of Flos Lonicerae. Exploration of the favorable climatic conditions for the development of the Flos Lonicerae planting industry in Yuepuhu provides a scientific basis for the construction of the Yuepuhu Flos Lonicerae industrial base, as well as the meteorological guarantee for the increase of income of flower farmers.