In order to make full use of the ecological environment characteristics, improve the yields and quality of Momordica grosvenori and promote the stable and efficient production, it is essential to scientifically formulate the plan of Momordica grosvenori production in Guilin. Based on the data of 14 meteorological stations in Guilin from 1981 to 2017 with combining with the Digital Elevation Model (DEM) data and using the method of Analytic Hierarchy Process (AHP), the climatic suitability index of Momordica grosvenori in Guilin is constructed by two factors of climate and terrain. The climatic suitability index is classified into suitable, subsuitable and unsuitable areas by using the method of Natural Breaks. The results show that the central, southwest and northeast parts of Guilin are more suitable for planting grosvenori with a good hydrothermal condition, suitable temperature and sunlight and moderate altitude. Besides, the Maoer Mountain, Yuecheng Mountain, Haiyang Mountain and Dupang Mountain in Guilin belong to unsuitable areas, for having higher altitude and worse climate condition and not meeting the needs of the growth and development of Momordica grosvenori.